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Monoclonal Gammopathy

Monoclonal gammopathy of undetermined significance (MGUS) is a rare condition caused by an overabundance of a certain protein in your blood. It is a diseases and condition in which a low or non-quantifiable level of a monoclonal paraprotein is detected in the blood by means of protein electrophoresis . Monoclonal gammopathy can occur in both sexes and in people of all backgrounds and occupations. In about 80 percent of cases, the abnormal protein does not cause any problems. These disorders do not usually cause symptoms, so they are almost always discovered by chance when laboratory tests are performed for other purposes, such as to measure protein in the blood. However, the monoclonal antibody can bind to nerves and lead to numbness, tingling, and weakness. Monoclonal gammopathy is present in 2 percent to 4 percent of adults older than age 50. The condition is often found on a routine blood test called plasma electrophoresis done for some other reason. Monoclonal gammopathy typically causes no signs or symptoms and doesn't require treatment. In most cases, monoclonal gammopathy is not related to a serious disorder. However, close follow-up is often recommended for people with monoclonal gammopathy due to their increased risk of cancer. About 1 percent of individuals with monoclonal gammopathy ultimately develop multiple myeloma or a related cancer. If you have a family history of multiple myeloma, talk to your doctor about whether testing for monoclonal gammopathy is appropriate for you.

A monoclonal gammopathy of undetermined significance is a buildup of monoclonal antibodies produced by abnormal but noncancerous plasma cells. A plasma cell is a type of white blood cell. These antibodies circulate in the blood, ready to attack any viruses and bacteria that may be present in the body. When an abnormally large amount of one particular antibody is produced, this is called monoclonal gammopathy. All the antibodies are identical. Sometimes, monoclonal gammopathy is called paraproteinaemia . The individual antibody that is being produced in large amounts is called an M-protein. Monoclonal gammopathy of unknown significance is a non-cancerous condition. The levels of antibody in MGUS, although raised, are not as high as the amount produced in people with myeloma   and some types of lymphoma.

Causes of Monoclonal Gammopathy

Common Causes of Monoclonal Gammopathy :

  • The cause of Monoclonal Gammopathy is unknown.
  • Monoclonal Gammopathy , like myeloma, is seen mainly in older people.
  • The mortality was increased for several other malignant and non-malignant causes of death during the first 4 years of follow-up. Monoclonal Gammopathy , like myeloma, is seen mainly in older people.

Symptoms of Monoclonal Gammopathy

Some common Symptoms of Monoclonal Gammopathy :

  • Weight loss.
  • Feeling very tired.
  • Night sweats.
  • Unexplained bruising or bleeding.
  • Colds and other infections.
  • Swollen lymph glands.

Treatment of Monoclonal Gammopathy

  • Monoclonal gammopathy has not been described in IVF patients previously, nor has monoclonal gammopathy been reported as a cause of erroneously elevated oestradiol concentration.
  • In addition, specific workup relative to the gammopathy should include a bone marrow examination, skeletal radiography (including single views of the humeri and femurs and complete spinal with optional lateral views), and a 24-hour urine collection for protein quantitation.
  • No treatment is recommended for patients with MGUS. However, if preventive clinical studies are available, patients should be encouraged to participate in such studies.